Gallopamil hydrochloride

Research use only, not for human use.

Gallopamil hydrochloride is an antagonist of phenylalkylamine calcium. Gallopamil hydrochloride can be used in antiarrhythmic and vasodilator studies.

Gallopamil hydrochloride is an antagonist of phenylalkylamine calcium. Gallopamil hydrochloride can be used in antiarrhythmic and vasodilator studies.(In Vitro):Gallopamil hydrochloride inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 μM. (In Vivo):In male Wistar rats, Gallopamil hydrochloride (0.2 mg/kg; i.v. for 5 min) markedly reduces ventricular tachycardia and totally prevents fibrillation. Gallopamil hydrochloride significantly reduces systolic and diastolic blood pressure measured 5 min after injection without markedly influencing heart rate.

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Gallopamil hydrochloride (Methoxyverapamil hydrochloride; i.v.; 0.2 mg/kg; for 5 min) markedly reduces ventricular tachycardia (VT) and totally prevents fibrillation (VF). Gallopamil significantly reduces systolic and diastolic blood pressure measured 5 min after injection without markedly influencing heart rate. Animal Model:Male Wistar rats weighing 290-370 g Dosage:0.2 mg/kg Administration:i.v.; 5 min Result:Markedly reduced VT and totally prevented VF.

Methoxyverapamil hydrochloride

GPCR/G Protein

Calcium Channel

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16662-46-7

521.1

C28H41ClN2O5

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (191.91 mM)

Cl.COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2cc(OC)c(OC)c(OC)c2)cc1OC

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(-20℃)

With Ice Pack

≥ 2 years